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浜嬪涓�锛�2021骞�10鏈堬紝Merus N. V.鏇惧牨鍛奙CLA-158鐨勫垵姝ヨ嚚搴婄爺绌舵暩(sh霉)鎿�(j霉)锛屽尟绺戒簡MCLA-158鍠棩娌荤檪鏅氭湡闋牳閮ㄩ睏鐧岋紙HNSCC锛夎嚚搴奍鏈熷姂閲忕埇鍧¤│椹椾腑鐨勫畨鍏ㄦ€�銆佽€愬彈鎬у拰鏈夋晥鎬х祼(ji茅)鏋�銆�7渚嬪彲瑭曚及鎮ｈ€呰叓鐦ら珨绌嶅叏閮ㄧ府灏忥紝3渚嬫偅鑰呴仈(d谩)鍒伴儴鍒嗙珐瑙�锛屽叾涓�1渚嬫偅鑰呭湪2021骞�8鏈堟暩(sh霉)鎿�(j霉)鎴鏃ユ湡鍚庣嵅寰楀畬鍏ㄧ珐瑙�銆�
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[1] Bram Herpers et al. Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR 脳LGR5 bispecific antibody with efficacy in epithelial tumors. Nature Cancer.2022.
[2]https://www.globenewswire.com/news-release/2022/04/25/2428080/37568/en/Merus-Announces-Publication-in-Nature-Cancer-on-Petosemtamab-s-MCLA-158-Unique-Mechanism-of-Action.html
[3] 棣彲閼瓑. 鑵槫椤炲櫒瀹樼殑鎳�(y墨ng)鐢ㄥ強灞曟湜. 涓湅鑵槫. 2022.
[4]https://medicalxpress.com/news/2022-04-discovery-mcla-clinical-candidate-screened.html
[5]https://www.globenewswire.com/news-release/2022/04/25/2428080/37568/en/Merus-Announces-Publication-in-Nature-Cancer-on-Petosemtamab-s-MCLA-158-Unique-Mechanism-of-Action.html
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